Protein Details: Acid-sensing ion channel 5
Protein ID
ICDB_Pro_1588
Protein Name
Acid-sensing ion channel 5
Gene Name
ASIC5; ACCN5; HINAC
Organism
Homo sapiens (Human)
Length
505 amino acids
AlphaFoldDB
AF-Q9NY37-F1-model_v4.pdb
Function
Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium;and is inhibited by amiloride.
Sequence
MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAFTDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC
PDB Structures
Ligand Binding
Binding Site
Disease
Pregnancy Loss;Recurrent 3 and Otitis Media
Location
Detected in small intestine;duodenum and jejunum. Detected at very low levels in testis and rectum.
DOI ID
10.1016/s0014-5793(00)01403-4
RefSeq
NP_059115.1